Nicotinic receptor subtypes differentially modulate glutamate release in the dorsal medial striatum.
Neurochem Int
; 100: 30-34, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27568861
ABSTRACT
The dorsal medial striatum is a crucial part of the neural network that subserves dynamic, goal-directed behaviors. Functional output of this nucleus is shaped, in part, by the influence of glutamatergic inputs. Striatal cholinergic systems have the capacity to modulate these excitatory inputs through presynaptic nicotinic acetylcholine receptors (nAChRs); however, the individual contribution of the two major nicotinic receptor subtypes, α4ß2 and α7, to such modulation is not well characterized. In the present experiments, glutamate biosensors were used to monitor nAChR-dependent glutamate release with high temporal precision in the dorsal medial striatum of rats. Both α4ß2 and α7 nAChRs were found to potently modulate glutamate release; however the two receptor subtypes do so in strikingly different ways. α7 nAChRs appear to enhance release from glutamatergic terminals. In contrast, α4ß2 nAChRs act as a brake on glutamate release via an interaction with local dopaminergic inputs and D2 receptors. Combined, the present data reveal the capacity of local striatal cholinergic signaling to dynamically modulate excitatory inputs through nAChRs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Nicotínicos
/
Terminações Pré-Sinápticas
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Ácido Glutâmico
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article