Ameliorating Active Ulcerative Colitis via an Orally Available Toll-Like Receptor-9 Modifier: A Prospective Open-Label, Multicenter Phase II Trial.

Dotan, Iris; Levy-Nissenbaum, Etgar; Chowers, Yehuda; Fich, Alexander; Israeli, Eran; Adar, Tomer; Shteingart, Shimon; Soreq, Hermona; Goldin, Eran

Dotan, Iris; Levy-Nissenbaum, Etgar; Chowers, Yehuda; Fich, Alexander; Israeli, Eran; Adar, Tomer; Shteingart, Shimon; Soreq, Hermona; Goldin, Eran.

Afiliação

Dotan I; Department of Gastroenterology and Liver Diseases, IBD Center, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv, Israel. irisd@tlvmc.gov.il.
Levy-Nissenbaum E; BioLineRx Ltd., Modi'in, Israel.
Chowers Y; Department of Gastroenterology, Rambam Health Care Campus, Bat Galim, Haifa, Israel.
Fich A; Department of Gastroenterology, Soroka Medical Center, Beer Sheba, Israel.
Israeli E; IBD Unit, Institute of Gastroenterology and Liver Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Adar T; Digestive Diseases Institute, Shaare Zedek Medical Center Affiliated with The Hebrew University, Jerusalem, Israel.
Shteingart S; Digestive Diseases Institute, Shaare Zedek Medical Center Affiliated with The Hebrew University, Jerusalem, Israel.
Soreq H; Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
Goldin E; Digestive Diseases Institute, Shaare Zedek Medical Center Affiliated with The Hebrew University, Jerusalem, Israel.

Dig Dis Sci ; 61(11): 3246-3254, 2016 11.

Article em En | MEDLINE | ID: mdl-27572942

Assuntos

Colite Ulcerativa/tratamento farmacológico; Oligodesoxirribonucleotídeos/uso terapêutico; Receptor Toll-Like 9/agonistas; Administração Oral; Adulto; Colite Ulcerativa/imunologia; Colite Ulcerativa/patologia; Colo/imunologia; Colo/patologia; Feminino; Humanos; Interleucina-10/imunologia; Interleucina-12/imunologia; Interleucina-1beta/imunologia; Interleucina-6/imunologia; Interleucina-8/imunologia; Mucosa Intestinal/imunologia; Mucosa Intestinal/patologia; Masculino; Pessoa de Meia-Idade; Neutrófilos/patologia; Resultado do Tratamento; Fator de Necrose Tumoral alfa/imunologia

Palavras-chave

Oral treatment; Pro-inflammatory cytokines; Synthetic oligonucleotide; Toll-like receptor-9; Ulcerative colitis

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Base de dados: MEDLINE Assunto principal: Oligodesoxirribonucleotídeos / Colite Ulcerativa / Receptor Toll-Like 9 Tipo de estudo: Clinical_trials / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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