Parental Psychiatric Disease and Risks of Attempted Suicide and Violent Criminal Offending in Offspring: A Population-Based Cohort Study.
JAMA Psychiatry
; 73(10): 1015-1022, 2016 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-27580483
ABSTRACT
IMPORTANCE Self-directed and interpersonal violence share some common risk factors such as a parental history of mental illness. However, relationships between the full spectrum of parental psychiatric disease and these 2 related outcomes are unclear. OBJECTIVE:
To examine associations between the full spectrum of parental psychiatric disease and risks of attempted suicide and violent offending among offspring. DESIGN, SETTING, ANDPARTICIPANTS:
Population-based cohort study of all persons born in Denmark 1967 through 1997, followed up from their 15th birthday until occurrence of adverse outcome or December 31, 2012, whichever came first. EXPOSURES Array of parental psychiatric disorders and parental suicide attempt, delineated from records of secondary care treatments. MAIN OUTCOMES ANDMEASURES:
Using survival analyses techniques, incidence rate ratios were estimated for offspring suicide attempt and violent offending.RESULTS:
We examined 1â¯743â¯525 cohort members (48.7% female; total follow-up, 27.2 million person-years). Risks for offspring suicide attempt and violent offending were elevated across virtually the full spectrum of parental psychiatric disease. Incidence rate ratios were the most elevated for parental diagnoses of antisocial personality disorder (suicide attempt, 3.96; 95% CI, 3.72-4.21; violent offending, 3.62; 95% CI, 3.41-3.84) and cannabis misuse (suicide attempt, 3.57; 95% CI, 3.25-3.92; violent offending, 4.05; 95% CI, 3.72-4.39), and for parental suicide attempt (suicide attempt, 3.42; 95% CI, 3.29-3.55; violent offending, 3.31; 95% CI, 3.19-3.44). Parental mood disorders (and bipolar disorder in particular) conferred more modest risk increases. A history of mental illness or suicide attempt in both parents was associated with double the risks compared with having just 1 affected parent. Associations between parental psychiatric disease and offspring violent offending were stronger for female than for male offspring, whereas little sex difference in risk was found for offspring suicide attempt. CONCLUSIONS AND RELEVANCE The similarities in risk patterns observed between the 2 outcomes may evidence a shared etiology. Early interventions to tackle parental mental disorders may be beneficial to both parents and children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pais
/
Tentativa de Suicídio
/
Violência
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Filho de Pais com Deficiência
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Crime
/
Transtornos Mentais
/
Transtorno da Personalidade Antissocial
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
Limite:
Adolescent
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Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article