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Identification of KasA as the cellular target of an anti-tubercular scaffold.
Abrahams, Katherine A; Chung, Chun-Wa; Ghidelli-Disse, Sonja; Rullas, Joaquín; Rebollo-López, María José; Gurcha, Sudagar S; Cox, Jonathan A G; Mendoza, Alfonso; Jiménez-Navarro, Elena; Martínez-Martínez, María Santos; Neu, Margarete; Shillings, Anthony; Homes, Paul; Argyrou, Argyrides; Casanueva, Ruth; Loman, Nicholas J; Moynihan, Patrick J; Lelièvre, Joël; Selenski, Carolyn; Axtman, Matthew; Kremer, Laurent; Bantscheff, Marcus; Angulo-Barturen, Iñigo; Izquierdo, Mónica Cacho; Cammack, Nicholas C; Drewes, Gerard; Ballell, Lluis; Barros, David; Besra, Gurdyal S; Bates, Robert H.
Afiliação
  • Abrahams KA; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Chung CW; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Ghidelli-Disse S; Cellzome-a GSK Company, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Rullas J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Rebollo-López MJ; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Gurcha SS; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Cox JA; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Mendoza A; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Jiménez-Navarro E; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Martínez-Martínez MS; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Neu M; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Shillings A; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Homes P; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Argyrou A; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Casanueva R; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Loman NJ; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Moynihan PJ; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Lelièvre J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Selenski C; GlaxoSmithKline, 709 Swedeland Road, PO Box 1539, King of Prussia, Pennsylvania 19406-0939, USA.
  • Axtman M; GlaxoSmithKline, 709 Swedeland Road, PO Box 1539, King of Prussia, Pennsylvania 19406-0939, USA.
  • Kremer L; Centre National de la Recherche Scientifique FRE 3689, Centre d'études d'agents Pathogènes et Biotechnologies pour la Santé, Université de Montpellier, 1919 route de Mende, 34293 Montpellier, France.
  • Bantscheff M; INSERM, CPBS, 34293 Montpellier, France.
  • Angulo-Barturen I; Cellzome-a GSK Company, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Izquierdo MC; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Cammack NC; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Drewes G; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Ballell L; Cellzome-a GSK Company, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  • Barros D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Besra GS; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Bates RH; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Nat Commun ; 7: 12581, 2016 09 01.
Article em En | MEDLINE | ID: mdl-27581223
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 3-Oxoacil-(Proteína de Transporte de Acila) Sintase / Sulfonamidas / Proteínas de Bactérias / Tuberculose Pulmonar / Indazóis / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 3-Oxoacil-(Proteína de Transporte de Acila) Sintase / Sulfonamidas / Proteínas de Bactérias / Tuberculose Pulmonar / Indazóis / Mycobacterium tuberculosis / Antituberculosos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article