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Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.
Leto, Gaetano; Incorvaia, Lorena; Flandina, Carla; Ancona, Chiara; Fulfaro, Fabio; Crescimanno, Marilena; Sepporta, Maria Vittoria; Badalamenti, Giuseppe.
Afiliação
  • Leto G; a Department of Sciences for Health Promotion , School of Medicine, University of Palermo , Palermo , Italy.
  • Incorvaia L; b Department of Surgical, Oncological and Oral Sciences , School of Medicine, University of Palermo , Palermo , Italy.
  • Flandina C; a Department of Sciences for Health Promotion , School of Medicine, University of Palermo , Palermo , Italy.
  • Ancona C; b Department of Surgical, Oncological and Oral Sciences , School of Medicine, University of Palermo , Palermo , Italy.
  • Fulfaro F; b Department of Surgical, Oncological and Oral Sciences , School of Medicine, University of Palermo , Palermo , Italy.
  • Crescimanno M; a Department of Sciences for Health Promotion , School of Medicine, University of Palermo , Palermo , Italy.
  • Sepporta MV; c Department of Chemistry, Biology and Biotechnologies , University of Perugia , Perugia , Italy.
  • Badalamenti G; b Department of Surgical, Oncological and Oral Sciences , School of Medicine, University of Palermo , Palermo , Italy.
Cancer Invest ; 34(9): 415-423, 2016 Oct 20.
Article em En | MEDLINE | ID: mdl-27636861
ABSTRACT
This study was directed to assess the clinical impact of the circulating cathepsin L, cystatin C, activin A, and follistatin in breast cancer patients. The serum concentrations of these molecules were determined by immunoenzymatic assays, and their association with some clinico-pathological parameters of breast cancer progression was evaluated. Our results identified cystatin C and activin A as predictive markers for the presence of breast cancer and bone metastasis, respectively. Therefore, these proteins may have a clinical role as circulating biomarkers in the diagnosis and therapeutic monitoring of breast cancer patients.
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Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Ativinas / Folistatina / Cistatina C / Catepsina L Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Buscar no Google
Imprimir
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PubMed Links

Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Ativinas / Folistatina / Cistatina C / Catepsina L Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article