[Application of benchmark dose on renal injury in people chronically exposed to lead].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 34(7): 494-497, 2016 Jul 20.
Article
em Zh
| MEDLINE
| ID: mdl-27682482
ABSTRACT
Objective:
To screen sensitive indicators of renal injury in lead workers using benchmark dose method.Methods:
Of the 486 subjects,116 did not occupationally contact to lead as a control. The blood lead was considered as exposure biomarker, while Uß2-MG and UNAG as effect biomarkers for renal injury. The BMD and BMDL of blood lead were estimated at the 10% benchmark response using BMDS Version 2.6.Results:
There was statistical rise in blood lead between the lead group and control group (P<0.05) ; and the blood lead level was divided into four groups by quarterback spacing method, among which UNAG was statistically different (P<0.05) . There was an increased prevalence of abnormal rates of Uß2-MG and UNAG with increasing blood lead concentration (P<0.05) , after trend chi-square test. BMD and BMDL of UNAG and Uß2-MG were 602.784/431.838 µg/L and 130.398/100.981 µg/L caculated by Log-Probit model, respectively.Conclusions:
Occupational lead exposure may cause kidney damage, and UNAG could be as a more sensitive marker for monitoring early renal injury than Uß2-MG.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Exposição Ocupacional
/
Nefropatias
/
Chumbo
/
Doenças Profissionais
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article