Quantification of Multiple Components of Complex Aluminum-Based Adjuvant Mixtures by Using Fourier Transform Infrared Spectroscopy and Partial Least Squares Modeling.
Methods Mol Biol
; 1494: 253-261, 2017.
Article
em En
| MEDLINE
| ID: mdl-27718199
ABSTRACT
Fourier transform infrared (FTIR) spectroscopy is widely used in the pharmaceutical industry for process monitoring, compositional quantification, and characterization of critical quality attributes in complex mixtures. Advantages over other spectroscopic measurements include ease of sample preparation, quantification of multiple components from a single measurement, and the ability to quantify optically opaque samples. This method describes the use of a multivariate model for quantifying a TLR4 agonist (GLA) adsorbed onto aluminum oxyhydroxide (Alhydrogel®) using FTIR spectroscopy that may be adapted to quantify other complex aluminum based adjuvant mixtures.
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Base de dados:
MEDLINE
Assunto principal:
Adjuvantes Imunológicos
/
Alumínio
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article