Pathophysiology, assessment and management of multiple sclerosis fatigue: an update.
Expert Rev Neurother
; 17(4): 373-379, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-27728987
ABSTRACT
INTRODUCTION:
Fatigue is one of the most common symptoms associated with multiple sclerosis, affecting almost 80% of patients with 55% of them reporting it as one of the worst symptoms experienced, often independently of the level of disability. Areas covered We review the main pathophysiological hypothesis, fatigue assessment scales, and its management. Expert commentary Fatigue pathophysiology is complex and is often influenced by other secondary but relevant factors (e.g. psychological disturbances, musculoskeletal problems, sleep disorders and medication side effects) which may vary over time. Both peripheral and central mechanisms are implicated. The large heterogeneity of the assessment scales, which were used in the therapeutic trials, is partially responsible for the uncertainty of their results. To date, the best therapeutic approach seems to be from a multidisciplinary management involving exercise, rehabilitation and education in conjunction with medication.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fadiga
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article