Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.

Huang, Stanley Ching-Cheng; Smith, Amber M; Everts, Bart; Colonna, Marco; Pearce, Erika L; Schilling, Joel D; Pearce, Edward J

Huang, Stanley Ching-Cheng; Smith, Amber M; Everts, Bart; Colonna, Marco; Pearce, Erika L; Schilling, Joel D; Pearce, Edward J.

Afiliação

Huang SC; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Smith AM; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Everts B; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Colonna M; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pearce EL; Department of Immunometabolism, Max Planck Institute for Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Schilling JD; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, MO 63
Pearce EJ; Department of Immunometabolism, Max Planck Institute for Immunobiology and Epigenetics, 79108 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany. Electronic address: pearceed@ie-freiburg.mpg.de.

Immunity ; 45(4): 817-830, 2016 10 18.

Article em En | MEDLINE | ID: mdl-27760338

Assuntos

Fatores Reguladores de Interferon/metabolismo; Ativação de Macrófagos/fisiologia; Macrófagos/fisiologia; Complexos Multiproteicos/metabolismo; Transdução de Sinais/fisiologia; Serina-Treonina Quinases TOR/metabolismo; Animais; Interleucina-4/metabolismo; Fator Estimulador de Colônias de Macrófagos/metabolismo; Macrófagos/metabolismo; Alvo Mecanístico do Complexo 2 de Rapamicina; Camundongos; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fator de Transcrição STAT6/metabolismo

Palavras-chave

cancer immunity; cytokine signaling; growth-factor signaling; macrophage; metabolism; type 2 immunity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Complexos Multiproteicos / Fatores Reguladores de Interferon / Serina-Treonina Quinases TOR / Ativação de Macrófagos / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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