Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses.
Magn Reson Med
; 78(3): 963-975, 2017 09.
Article
em En
| MEDLINE
| ID: mdl-27770458
ABSTRACT
PURPOSE:
Balanced steady-state free precession (bSSFP) sequences can provide superior signal-to-noise ratio efficiency for hyperpolarized (HP) carbon-13 (13 C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in the context of metabolic imaging. A new spectrally selective bSSFP sequence was developed for fast imaging of multiple HP 13 C metabolites with high spatiotemporal resolution. THEORY ANDMETHODS:
This novel approach for bSSFP spectral selectivity incorporates optimized short-duration spectrally selective radiofrequency pulses within a bSSFP pulse train and a carefully chosen repetition time to avoid banding artifacts.RESULTS:
The sequence enabled subsecond 3D dynamic spectrally selective imaging of 13 C metabolites of copolarized [1-13 C]pyruvate and [13 C]urea at 2-mm isotropic resolution, with excellent spectral selectivity (â¼1001). The sequence was successfully tested in phantom studies and in vivo studies with normal mice.CONCLUSION:
This sequence is expected to benefit applications requiring dynamic volumetric imaging of metabolically active 13 C compounds at high spatiotemporal resolution, including preclinical studies at high field and, potentially, clinical studies. Magn Reson Med 78963-975, 2017. © 2016 International Society for Magnetic Resonance in Medicine.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Isótopos de Carbono
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Imageamento por Ressonância Magnética
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Imageamento Tridimensional
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article