Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa.
Pharmacogenomics J
; 17(2): 112-120, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27779243
ABSTRACT
As the common birthplace of all human populations, modern humans have lived longer on the African continent than in any other geographical region of the world. This long history, along with the evolutionary need to adapt to environmental challenges such as exposure to infectious agents, has led to greater genetic variation in Africans. The vast genetic variation in Africans also extends to genes involved in the absorption, distribution, metabolism and excretion of pharmaceuticals. Ongoing cataloging of these clinically relevant variants reveals huge allele-frequency differences within and between African populations. Here, we examine Africa's large burden of infectious disease, discuss key examples of known genetic variation modulating disease risk, and provide examples of clinically relevant variants critical for establishing dosing guidelines. We propose that a more systematic characterization of the genetic diversity of African ancestry populations is required if the current benefits of precision medicine are to be extended to these populations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
/
Doenças Transmissíveis
/
Evolução Molecular
/
População Negra
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Variantes Farmacogenômicos
/
Anti-Infecciosos
Tipo de estudo:
Guideline
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article