Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-ß and C/EBP-&#945; genome-wide binding during liver regeneration.

Kuttippurathu, Lakshmi; Patra, Biswanath; Cook, Daniel; Hoek, Jan B; Vadigepalli, Rajanikanth

Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-ß and C/EBP-α genome-wide binding during liver regeneration.

Kuttippurathu, Lakshmi; Patra, Biswanath; Cook, Daniel; Hoek, Jan B; Vadigepalli, Rajanikanth.

Afiliação

Kuttippurathu L; Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Patra B; Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Cook D; Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Hoek JB; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware; and.
Vadigepalli R; Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Physiol Genomics ; 49(1): 11-26, 2017 01 01.

Article em En | MEDLINE | ID: mdl-27815535

Assuntos

Proteína alfa Estimuladora de Ligação a CCAAT/genética; Proteína beta Intensificadora de Ligação a CCAAT/genética; Etanol/toxicidade; Genoma; Hepatopatias Alcoólicas/genética; Regeneração Hepática/efeitos dos fármacos; Animais; Anti-Infecciosos Locais/toxicidade; Regulação da Expressão Gênica/efeitos dos fármacos; Hepatectomia/efeitos adversos; Hepatopatias Alcoólicas/etiologia; Masculino; Ratos; Ratos Sprague-Dawley

Palavras-chave

C/EBP-α; C/EBP-ß; ChIP-seq; chromatin immunoprecipitation; ethanol; liver regeneration; partial hepatectomy; pattern analysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma / Proteína alfa Estimuladora de Ligação a CCAAT / Proteína beta Intensificadora de Ligação a CCAAT / Etanol / Hepatopatias Alcoólicas / Regeneração Hepática Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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