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Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037.
Haagensen, Emma J; Thomas, Huw D; Schmalix, Wolfgang A; Payne, Andrew C; Kevorkian, Lara; Allen, Rodger A; Bevan, Paul; Maxwell, Ross J; Newell, David R.
Afiliação
  • Haagensen EJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.
  • Thomas HD; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.
  • Schmalix WA; Wilex AG, Grillparzerstrasse 18, 81675, Munich, Germany.
  • Payne AC; UCB Pharma Ltd, 208 Bath Road, Slough, SL1 3WE, UK.
  • Kevorkian L; UCB Pharma Ltd, 208 Bath Road, Slough, SL1 3WE, UK.
  • Allen RA; UCB Pharma Ltd, 208 Bath Road, Slough, SL1 3WE, UK.
  • Bevan P; Wilex AG, Grillparzerstrasse 18, 81675, Munich, Germany.
  • Maxwell RJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.
  • Newell DR; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK. herbie.newell@ncl.ac.uk.
Cancer Chemother Pharmacol ; 78(6): 1269-1281, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27837257
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Quinases de Proteína Quinase Ativadas por Mitógeno / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Protocolos de Quimioterapia Combinada Antineoplásica / Quinases de Proteína Quinase Ativadas por Mitógeno / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article