Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design.

Cao, Xiaocong; Li, Yajuan; Jin, Xiangyu; Li, Yuelong; Guo, Feng; Jin, Tengchuan

Cao, Xiaocong; Li, Yajuan; Jin, Xiangyu; Li, Yuelong; Guo, Feng; Jin, Tengchuan.

Afiliação

Cao X; Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China.
Li Y; Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China lyj106@mail.ustc.edu.cn.
Jin X; Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China.
Li Y; Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China.
Guo F; School of Medicine, Stanford University, Stanford, CA 94305, USA.
Jin T; Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China jint@ustc.edu.cn.

Nucleic Acids Res ; 44(21): 10505-10514, 2016 Dec 01.

Article em En | MEDLINE | ID: mdl-27915293

Assuntos

Antivirais/química; Antivirais/farmacologia; Desenho de Fármacos; Proteínas não Estruturais Virais/química; Proteínas não Estruturais Virais/metabolismo; Zika virus/efeitos dos fármacos; Zika virus/enzimologia; Sítios de Ligação; Humanos; Hidrólise; Metais/química; Metais/metabolismo; Modelos Moleculares; Conformação Molecular; Ligação Proteica; Domínios e Motivos de Interação entre Proteínas; RNA Helicases/antagonistas & inibidores; RNA Helicases/química; RNA Helicases/genética; RNA Helicases/metabolismo; Proteínas Recombinantes; Serina Endopeptidases/química; Serina Endopeptidases/genética; Serina Endopeptidases/metabolismo; Relação Estrutura-Atividade; Proteínas não Estruturais Virais/antagonistas & inibidores; Proteínas não Estruturais Virais/genética; Zika virus/genética; Infecção por Zika virus/tratamento farmacológico; Infecção por Zika virus/virologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Desenho de Fármacos / Proteínas não Estruturais Virais / Zika virus Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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