Immune Cell Intolerance for Excess Cholesterol.

Widenmaier, Scott B; Hotamisligil, Gökhan S

Widenmaier, Scott B; Hotamisligil, Gökhan S.

Afiliação

Widenmaier SB; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Hotamisligil GS; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ghotamis@hsph.harvard.edu.

Immunity ; 45(6): 1186-1188, 2016 12 20.

Article em En | MEDLINE | ID: mdl-28002726

ABSTRACT

ABSTRACT

Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects in cholesterol metabolism in CD11c+ immune cells result in impaired antigen presentation and ultimately in autoimmune disease.

Assuntos

Apresentação de Antígeno; Colesterol; Doenças Autoimunes; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colesterol / Apresentação de Antígeno Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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