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MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.
Mollaoglu, Gurkan; Guthrie, Matthew R; Böhm, Stefanie; Brägelmann, Johannes; Can, Ismail; Ballieu, Paul M; Marx, Annika; George, Julie; Heinen, Christine; Chalishazar, Milind D; Cheng, Haixia; Ireland, Abbie S; Denning, Kendall E; Mukhopadhyay, Anandaroop; Vahrenkamp, Jeffery M; Berrett, Kristofer C; Mosbruger, Timothy L; Wang, Jun; Kohan, Jessica L; Salama, Mohamed E; Witt, Benjamin L; Peifer, Martin; Thomas, Roman K; Gertz, Jason; Johnson, Jane E; Gazdar, Adi F; Wechsler-Reya, Robert J; Sos, Martin L; Oliver, Trudy G.
Afiliação
  • Mollaoglu G; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Guthrie MR; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Böhm S; Molecular Pathology, Institute for Pathology, Medical Faculty, University of Cologne, 50937 Cologne, Germany; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  • Brägelmann J; Molecular Pathology, Institute for Pathology, Medical Faculty, University of Cologne, 50937 Cologne, Germany; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  • Can I; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Ballieu PM; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Marx A; Molecular Pathology, Institute for Pathology, Medical Faculty, University of Cologne, 50937 Cologne, Germany; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  • George J; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  • Heinen C; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  • Chalishazar MD; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Cheng H; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Ireland AS; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Denning KE; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Mukhopadhyay A; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Vahrenkamp JM; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Berrett KC; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Mosbruger TL; Huntsman Cancer Institute, Bioinformatics Shared Resource, Salt Lake City, UT 84112, USA.
  • Wang J; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Kohan JL; Department of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, UT 84112, USA.
  • Salama ME; Department of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, UT 84112, USA.
  • Witt BL; Department of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, UT 84112, USA.
  • Peifer M; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.
  • Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany; Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120
  • Gertz J; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
  • Johnson JE; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Gazdar AF; Department of Pathology, Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX 75235, USA.
  • Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Sos ML; Molecular Pathology, Institute for Pathology, Medical Faculty, University of Cologne, 50937 Cologne, Germany; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. Electronic address: martin.sos@uni-koeln.de.
  • Oliver TG; Department of Oncological Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. Electronic address: trudy.oliver@hci.utah.edu.
Cancer Cell ; 31(2): 270-285, 2017 02 13.
Article em En | MEDLINE | ID: mdl-28089889
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-myc / Inibidores de Proteínas Quinases / Carcinoma de Pequenas Células do Pulmão / Aurora Quinases / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-myc / Inibidores de Proteínas Quinases / Carcinoma de Pequenas Células do Pulmão / Aurora Quinases / Neoplasias Pulmonares Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article