Lynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1.
Bioorg Med Chem
; 25(5): 1622-1629, 2017 03 01.
Article
em En
| MEDLINE
| ID: mdl-28139279
ABSTRACT
The first total synthesis of the antimicrobial natural product lynamicin D has been developed using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the biological activity of lynamicin D reveals that it has a minor effect on cell viability but it can modulate splicing of pre-mRNAs. We provide evidence that this effect is mainly due to the ability of lynamicin D to alter the levels of SRPK1, the key kinase involved in both constitutive and alternative splicing.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
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Proteínas Serina-Treonina Quinases
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Processamento Alternativo
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Indóis
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article