Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif.

Pauty, Joris; Couturier, Anthony M; Rodrigue, Amélie; Caron, Marie-Christine; Coulombe, Yan; Dellaire, Graham; Masson, Jean-Yves

Pauty, Joris; Couturier, Anthony M; Rodrigue, Amélie; Caron, Marie-Christine; Coulombe, Yan; Dellaire, Graham; Masson, Jean-Yves.

Afiliação

Pauty J; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R 2J6, Canada.
Couturier AM; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Laval University, Québec City, QC G1V 0A6, Canada.
Rodrigue A; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R 2J6, Canada.
Caron MC; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Laval University, Québec City, QC G1V 0A6, Canada.
Coulombe Y; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R 2J6, Canada.
Dellaire G; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Laval University, Québec City, QC G1V 0A6, Canada.
Masson JY; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R 2J6, Canada.

Nucleic Acids Res ; 45(5): 2644-2657, 2017 03 17.

Article em En | MEDLINE | ID: mdl-28158555

Assuntos

Mutação; Neoplasias/genética; Proteínas Nucleares/genética; Proteínas Supressoras de Tumor/genética; Citoplasma/metabolismo; DNA/metabolismo; Proteína do Grupo de Complementação N da Anemia de Fanconi; Células HEK293; Humanos; Carioferinas/metabolismo; Sinais de Exportação Nuclear; Proteínas Nucleares/química; Proteínas Nucleares/metabolismo; Rad51 Recombinase/metabolismo; Receptores Citoplasmáticos e Nucleares/metabolismo; Deleção de Sequência; Proteínas Supressoras de Tumor/química; Proteínas Supressoras de Tumor/metabolismo; Repetições WD40; Proteína Exportina 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteínas Supressoras de Tumor / Mutação / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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