Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial.
BMC Cancer
; 17(1): 110, 2017 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-28173776
ABSTRACT
The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia (CIN). The lagging inclusions were mainly due to a strong patient preference for either of the two treatment modalities. This prompted us to initiate a new study on the same subject, with a non-randomized, open-label design:
the 'TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC)-3' study. Original TOPIC-trial Medical Ethics Committee approval number METC13231; ClinicalTrials.gov Identifier NCT02329171, 22 December 2014. TOPIC-3 study Medical Ethics Committee approval number METC162025; ClinicalTrials.gov Identifier NCT02917746, 16 September 2016.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Displasia do Colo do Útero
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Neoplasias do Colo do Útero
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Aminoquinolinas
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article