Manganese-Catalyzed C-H Alkynylation: Expedient Peptide Synthesis and Modification.
Angew Chem Int Ed Engl
; 56(12): 3172-3176, 2017 03 13.
Article
em En
| MEDLINE
| ID: mdl-28181732
ABSTRACT
Manganese(I)-catalyzed C-H alkynylations with organic halides occurred with unparalleled substrate scope, and thus enabled step-economical C-H functionalizations with silyl, aryl, alkenyl, and alkyl haloalkynes. The versatility of the manganese(I) catalysis manifold enabled C-H couplings with haloalkynes featuring, among others, fluorescent labels, steroids, and amino acids, thereby setting the stage for peptide ligation as well as the efficient molecular assembly of acyclic and cyclic peptides. A plausible catalytic cycle was proposed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Alcinos
/
Manganês
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article