<i>Mycobacterium tuberculosis</i> EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages.

Sengupta, Srabasti; Naz, Saba; Das, Ishani; Ahad, Abdul; Padhi, Avinash; Naik, Sumanta Kumar; Ganguli, Geetanjali; Pattanaik, Kali Prasad; Raghav, Sunil Kumar; Nandicoori, Vinay Kumar; Sonawane, Avinash

Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages.

Sengupta, Srabasti; Naz, Saba; Das, Ishani; Ahad, Abdul; Padhi, Avinash; Naik, Sumanta Kumar; Ganguli, Geetanjali; Pattanaik, Kali Prasad; Raghav, Sunil Kumar; Nandicoori, Vinay Kumar; Sonawane, Avinash.

Afiliação

Sengupta S; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India.
Naz S; the National Institute of Immunology, New Delhi, Delhi 110067, India, and.
Das I; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India.
Ahad A; the Institute of Life Science, Nalco Square, Bhubaneswar, Orissa 751023, India.
Padhi A; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India.
Naik SK; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India.
Ganguli G; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India.
Pattanaik KP; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India.
Raghav SK; the Institute of Life Science, Nalco Square, Bhubaneswar, Orissa 751023, India.
Nandicoori VK; the National Institute of Immunology, New Delhi, Delhi 110067, India, and.
Sonawane A; From the School of Biotechnology, KIIT University, Bhubaneswar, Orissa 751024, India, asonawane@kiitbiotech.ac.in.

J Biol Chem ; 292(17): 6855-6868, 2017 04 28.

Article em En | MEDLINE | ID: mdl-28209712

Assuntos

Proteínas de Bactérias/fisiologia; Metilação de DNA; Macrófagos/metabolismo; Mycobacterium bovis/metabolismo; Mycobacterium tuberculosis/metabolismo; Proteínas Nucleares/genética; Transativadores/genética; Animais; Apresentação de Antígeno; Antígenos de Bactérias/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Genoma Bacteriano; Histonas/metabolismo; Humanos; Interleucina-10/metabolismo; Interleucina-2/metabolismo; Interleucina-6/metabolismo; Sistema de Sinalização das MAP Quinases; Camundongos; Mutação; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Células RAW 264.7; Transdução de Sinais; Baço/citologia; Linfócitos T/citologia; Fator de Necrose Tumoral alfa/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

EsxL; Mycobacterium smegmatis; Mycobacterium tuberculosis; histone methylation; macrophage; major histocompatibility complex (MHC); nitric oxide; nitric oxide synthase; p38 MAPK

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Proteínas Nucleares / Transativadores / Metilação de DNA / Macrófagos / Mycobacterium bovis / Mycobacterium tuberculosis Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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