Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca<sup>2+</sup>/Mn<sup>2+</sup>-transport ATPase (SPCA1a).

Chen, Jialin; De Raeymaecker, Joren; Hovgaard, Jannik Brøndsted; Smaardijk, Susanne; Vandecaetsbeek, Ilse; Wuytack, Frank; Møller, Jesper Vuust; Eggermont, Jan; De Maeyer, Marc; Christensen, Søren Brøgger; Vangheluwe, Peter

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca²⁺/Mn²⁺-transport ATPase (SPCA1a).

Chen, Jialin; De Raeymaecker, Joren; Hovgaard, Jannik Brøndsted; Smaardijk, Susanne; Vandecaetsbeek, Ilse; Wuytack, Frank; Møller, Jesper Vuust; Eggermont, Jan; De Maeyer, Marc; Christensen, Søren Brøgger; Vangheluwe, Peter.

Afiliação

Chen J; From the Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, and.
De Raeymaecker J; Biochemistry, Molecular and Structural Biology Section, Department of Chemistry, KU Leuven, 3000 Leuven, Belgium.
Hovgaard JB; the Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark, and.
Smaardijk S; From the Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, and.
Vandecaetsbeek I; From the Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, and.
Wuytack F; From the Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, and.
Møller JV; the Department of Biomedicine, University of Aarhus, 8000 Aarhus, Denmark.
Eggermont J; From the Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, and.
De Maeyer M; Biochemistry, Molecular and Structural Biology Section, Department of Chemistry, KU Leuven, 3000 Leuven, Belgium.
Christensen SB; the Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark, and.
Vangheluwe P; From the Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, and peter.vangheluwe@kuleuven.be.

J Biol Chem ; 292(17): 6938-6951, 2017 04 28.

Article em En | MEDLINE | ID: mdl-28264934

Assuntos

ATPases Transportadoras de Cálcio/antagonistas & inibidores; ATPases Transportadoras de Cálcio/química; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/antagonistas & inibidores; Tapsigargina/química; Animais; Antineoplásicos/uso terapêutico; Neoplasias da Mama/tratamento farmacológico; Cálcio/química; Colesterol/química; Desenho de Fármacos; Feminino; Humanos; Hidroquinonas/química; Indóis/química; Ácidos Linoleicos/química; Lipossomos/química; Masculino; Mutagênese Sítio-Dirigida; Ácidos Oleicos/química; Ácidos Fosfatídicos/química; Neoplasias da Próstata/tratamento farmacológico; Ligação Proteica; Conformação Proteica; Coelhos; Proteínas Recombinantes/química; Saccharomyces cerevisiae/metabolismo; ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/química; Esfingomielinas/química; Relação Estrutura-Atividade

Palavras-chave

Golgi; calcium transport; cholesterol; cyclopiazonic acid; membrane transporter reconstitution; molecular modeling; prostate cancer; protein purification; thapsigargin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: ATPases Transportadoras de Cálcio / Tapsigargina / ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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