Dual-agonist occupancy of orexin receptor 1 and cholecystokinin A receptor heterodimers decreases G-protein-dependent signaling and migration in the human colon cancer cell line HT-29.

Bai, Bo; Chen, Xiaoyu; Zhang, Rumin; Wang, Xin; Jiang, Yunlu; Li, Dandan; Wang, Zhengwen; Chen, Jing

Bai, Bo; Chen, Xiaoyu; Zhang, Rumin; Wang, Xin; Jiang, Yunlu; Li, Dandan; Wang, Zhengwen; Chen, Jing.

Afiliação

Bai B; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China.
Chen X; Department of physiology, Taishan Medical University, Taian, Shandong 271000, People's Republic of China.
Zhang R; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China.
Wang X; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China.
Jiang Y; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China.
Li D; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China.
Wang Z; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China.
Chen J; Neurobiology Institute, Jining Medical University, Jining, Shandong 272067, People's Republic of China; Division of Translational and Systems Medicine, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom. Electronic address: jing.chen@warwick.ac.uk.

Biochim Biophys Acta Mol Cell Res ; 1864(7): 1153-1164, 2017 Jul.

Article em En | MEDLINE | ID: mdl-28288880

Assuntos

Movimento Celular; Subunidades alfa de Proteínas de Ligação ao GTP/metabolismo; Receptores de Orexina/metabolismo; Multimerização Proteica; Receptor de Colecistocinina A/metabolismo; Transdução de Sinais; Células HEK293; Células HT29; Humanos; Receptores de Orexina/genética; Ligação Proteica; Domínios Proteicos; Receptor de Colecistocinina A/genética; beta-Arrestinas/metabolismo

Palavras-chave

Bioluminescence resonance energy transfer (BRET); Cholecystokinin A receptor; Förster resonance energy transfer (FRET); G-proteincoupled receptor (GPCR); Heterodimerization; Migration; Orexin (hypocretin) receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Movimento Celular / Subunidades alfa de Proteínas de Ligação ao GTP / Receptor de Colecistocinina A / Multimerização Proteica / Receptores de Orexina Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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