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Total Synthesis of (±)-Grandilodine B.
Wang, Chunyu; Wang, Zhonglei; Xie, Xiaoni; Yao, Xiaotong; Li, Guang; Zu, Liansuo.
Afiliação
  • Wang C; School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
  • Wang Z; School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
  • Xie X; School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
  • Yao X; School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
  • Li G; School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
  • Zu L; School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.
Org Lett ; 19(7): 1828-1830, 2017 04 07.
Article em En | MEDLINE | ID: mdl-28294627
ABSTRACT
The first total synthesis of the opened-type Kopsia alkaloid grandilodine B is reported. Four stereocenters of this alkaloid, three of them quaternary, are stereoselectively generated by a Diels-Alder reaction, a diastereoselective cyanation of tertiary alcohol, and a facial-selective nitrone 1,3-dipolar cycloaddition.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article