HX-1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression.
J Cell Biochem
; 118(10): 3372-3380, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28300285
ABSTRACT
HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a novel synthesized vitamin E derivative, which reportedly has positive effects on various diseases and conditions, such as liver fibrosis, hepatic cirrhosis, and cancer. In this study, we analyzed the transcriptional activity induced by HX-1171. Results from reverse transcription polymerase chain reaction and promoter assays reveal that HX-1171 increased the expression of NQO1 and HMOX1, encoding antioxidant-related enzymes, in A549 human lung epithelial cells. The activity of nuclear factor-E2-related factor (Nrf2), a key transcriptional factor for antioxidative enzymes, was examined in HX-1171-treated cells. Confocal microscopy and Western blotting showed that HX-1171 effectively induced the nuclear translocation and transcriptional activity of Nrf2. We conclude that HX-1171, a novel Nrf2 activator, may be a promising therapeutic agent for oxidative stress-induced diseases. J. Cell. Biochem. 118 3372-3380, 2017. © 2017 Wiley Periodicals, Inc.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Regulação da Expressão Gênica
/
NAD(P)H Desidrogenase (Quinona)
/
Heme Oxigenase-1
/
Fator 2 Relacionado a NF-E2
/
Hidroquinonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article