A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer.

Thomas, M; Sadjadian, P; Kollmeier, J; Lowe, J; Mattson, P; Trout, J R; Gargano, M; Patchen, M L; Walsh, R; Beliveau, M; Marier, J F; Bose, N; Gorden, K; Schneller, F

Thomas, M; Sadjadian, P; Kollmeier, J; Lowe, J; Mattson, P; Trout, J R; Gargano, M; Patchen, M L; Walsh, R; Beliveau, M; Marier, J F; Bose, N; Gorden, K; Schneller, F.

Afiliação

Thomas M; Internistische Onkologie der Thoraxtumoren, Thoraxklinik im Universitätsklinikum Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Amalienstrasse 5, 69126, Heidelberg, Germany.
Sadjadian P; Johannes Wesling Medical Center Minden, Clinic Hematology/Oncology, Hans-Nolte-Str. 1, 32429, Minden, Germany.
Kollmeier J; Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Specialist Department 1: Clinic for Pneumology, Pneumology Oncology, Walterhöferstr.11, 14165, Berlin, Germany.
Lowe J; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA.
Mattson P; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA.
Trout JR; Rutgers University, 82 Rittenhouse Circle, Newtown, PA, 18940, USA.
Gargano M; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA.
Patchen ML; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA. mpatchen@immunoresearch.com.
Walsh R; Immuno Research, Inc., 3388 Mike Collins Drive, Suite B, Eagan, MN, 55121, USA. mpatchen@immunoresearch.com.
Beliveau M; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA.
Marier JF; Pharsight/Certara, Pharsight - A Certara™ Company, 2000 Peel Street, Suite 570, Montréal, Québec, H3A 2W5, Canada.
Bose N; Pharsight/Certara, Pharsight - A Certara™ Company, 2000 Peel Street, Suite 570, Montréal, Québec, H3A 2W5, Canada.
Gorden K; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA.
Schneller F; Biothera Pharmaceuticals Inc., 3388 Mike Collins Drive, Suite A, Eagan, MN, 55121, USA.

Invest New Drugs ; 35(3): 345-358, 2017 06.

Article em En | MEDLINE | ID: mdl-28303530

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Carboplatina/uso terapêutico; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Cetuximab/uso terapêutico; Glucanos/uso terapêutico; Neoplasias Pulmonares/tratamento farmacológico; Paclitaxel/uso terapêutico; Adulto; Idoso; Antineoplásicos/efeitos adversos; Antineoplásicos/sangue; Antineoplásicos/farmacocinética; Antineoplásicos/uso terapêutico; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Carboplatina/efeitos adversos; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Cetuximab/efeitos adversos; Feminino; Glucanos/efeitos adversos; Glucanos/sangue; Glucanos/farmacocinética; Humanos; Estimativa de Kaplan-Meier; Neoplasias Pulmonares/metabolismo; Masculino; Pessoa de Meia-Idade; Paclitaxel/efeitos adversos; Resultado do Tratamento

Palavras-chave

Beta glucan; Biomarker; Cetuximab; Immunotherapy; NSCLC

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Carboplatina / Paclitaxel / Carcinoma Pulmonar de Células não Pequenas / Cetuximab / Glucanos / Neoplasias Pulmonares Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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