Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction.

Tohme, Samer; Yazdani, Hamza O; Liu, Yao; Loughran, Patricia; van der Windt, Dirk J; Huang, Hai; Simmons, Richard L; Shiva, Sruti; Tai, Sheng; Tsung, Allan

Tohme, Samer; Yazdani, Hamza O; Liu, Yao; Loughran, Patricia; van der Windt, Dirk J; Huang, Hai; Simmons, Richard L; Shiva, Sruti; Tai, Sheng; Tsung, Allan.

Afiliação

Tohme S; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Yazdani HO; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Liu Y; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Loughran P; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
van der Windt DJ; Center for Biologic Imaging, Department of Cell Biology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Huang H; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Simmons RL; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Shiva S; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Tai S; Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA.
Tsung A; Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Hepatology ; 66(1): 182-197, 2017 07.

Article em En | MEDLINE | ID: mdl-28370295

Assuntos

Carcinoma Hepatocelular/genética; Proteína HMGB1/genética; Neoplasias Hepáticas/genética; Biogênese de Organelas; Receptor Toll-Like 9/metabolismo; Animais; Carcinoma Hepatocelular/patologia; Hipóxia Celular; Sobrevivência Celular; Humanos; Neoplasias Hepáticas/patologia; Neoplasias Hepáticas Experimentais/genética; Neoplasias Hepáticas Experimentais/patologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Distribuição Aleatória; Transdução de Sinais; Ativação Transcricional; Células Tumorais Cultivadas

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biogênese de Organelas / Carcinoma Hepatocelular / Proteína HMGB1 / Receptor Toll-Like 9 / Neoplasias Hepáticas Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google