Chromosome abnormalities in acute promyelocytic leukemia (APL).
Cancer
; 43(2): 558-62, 1979 Feb.
Article
em En
| MEDLINE
| ID: mdl-283877
ABSTRACT
Sixteen patients, 15 adults and one child, with APL have been studied cytogenetically; 14 of these had an abnormal karyotype (87%). Eleven of these consistently showed a t(15;17)(q26;q22) structural anomaly, one patient showed a 47,+8 karyotype, one a rearrangement of chromosomes No. 15 and No. 17, apparently different from that in the other patients, and one a No. 17 deletion without a demonstrable translocation. as an additional chromosome change trisomy No. 8 was found in 5 cases and monosomy No. 7 in two. The t)15;17)(q26;q22) structural anomaly is highly characteristic of APL, is found in APL of children and adults, but it is apparently not associated with a clinically different form of APL.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Aberrações Cromossômicas
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Cromossomos Humanos 13-15
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Cromossomos Humanos 16-18
Limite:
Adult
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Aged
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Female
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article