Tropism, intracerebral distribution, and transduction efficiency of HIV- and SIV-based lentiviral vectors after injection into the mouse brain: a qualitative and quantitative in vivo study.

Hlavatý, Juraj; Tonar, Zbynek; Renner, Matthias; Panitz, Sylvia; Petznek, Helga; Schweizer, Matthias; Schüle, Silke; Kloke, Björn-Philipp; Moldzio, Rudolf; Witter, Kirsti

Hlavatý, Juraj; Tonar, Zbynek; Renner, Matthias; Panitz, Sylvia; Petznek, Helga; Schweizer, Matthias; Schüle, Silke; Kloke, Björn-Philipp; Moldzio, Rudolf; Witter, Kirsti.

Afiliação

Hlavatý J; Department of Pathobiology, Institute of Anatomy, Histology and Embryology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria. juraj.hlavaty@vetmeduni.ac.at.
Tonar Z; Faculty of Applied Sciences, European Centre of Excellence NTIS, University of West Bohemia in Pilsen, Univerzitní 8, 306 14, Pilsen, Czech Republic.
Renner M; Department of Medicinal Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Panitz S; Department of Medicinal Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Petznek H; Institute of Virology, University of Veterinary Medicine, Vienna, Austria.
Schweizer M; Department of Medicinal Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Schüle S; Department of Medicinal Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Kloke BP; Department of Medicinal Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Moldzio R; Institute of Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Witter K; Department of Pathobiology, Institute of Anatomy, Histology and Embryology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria.

Histochem Cell Biol ; 148(3): 313-329, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28397143

Assuntos

Encéfalo/virologia; Vetores Genéticos/farmacocinética; HIV-1/metabolismo; HIV-2/metabolismo; Lentivirus/genética; Vírus da Imunodeficiência Símia/metabolismo; Transdução Genética/métodos; Tropismo Viral; Animais; Encéfalo/metabolismo; Células Cultivadas; Feminino; Vetores Genéticos/administração & dosagem; Vetores Genéticos/genética; HIV-1/genética; HIV-2/genética; Lentivirus/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Gravidez; Pesquisa Qualitativa; Vírus da Imunodeficiência Símia/genética

Palavras-chave

Double immunofluorescence; EGFP; Gene transfer; Stereology; Vpr; Vpx

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução Genética / Encéfalo / HIV-1 / HIV-2 / Vírus da Imunodeficiência Símia / Lentivirus / Tropismo Viral / Vetores Genéticos Tipo de estudo: Qualitative_research Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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