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Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Walker, Ann L; Ancellin, Nicolas; Beaufils, Benjamin; Bergeal, Marylise; Binnie, Margaret; Bouillot, Anne; Clapham, David; Denis, Alexis; Haslam, Carl P; Holmes, Duncan S; Hutchinson, Jonathan P; Liddle, John; McBride, Andrew; Mirguet, Olivier; Mowat, Christopher G; Rowland, Paul; Tiberghien, Nathalie; Trottet, Lionel; Uings, Iain; Webster, Scott P; Zheng, Xiaozhong; Mole, Damian J.
Afiliação
  • Walker AL; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Ancellin N; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Beaufils B; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Bergeal M; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK.
  • Binnie M; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK.
  • Bouillot A; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Clapham D; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK.
  • Denis A; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Haslam CP; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK.
  • Holmes DS; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Hutchinson JP; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK.
  • Liddle J; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • McBride A; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK.
  • Mirguet O; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Mowat CG; EastChem School of Chemistry, University of Edinburgh , Edinburgh EH9 3FJ, UK.
  • Rowland P; Platform Technology Sciences, GlaxoSmithKline Stevenage SG1 2NY, UK.
  • Tiberghien N; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Trottet L; Flexible Discovery Unit, GlaxoSmithKline , Paris, France.
  • Uings I; Discovery Partnerships with Academia, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Webster SP; Centre for Cardiovascular Science, University of Edinburgh , Edinburgh EH16 4TJ, UK.
  • Zheng X; MRC Centre for Inflammation Research, University of Edinburgh , Edinburgh EH16 4TJ, UK.
  • Mole DJ; MRC Centre for Inflammation Research, University of Edinburgh , Edinburgh EH16 4TJ, UK.
J Med Chem ; 60(8): 3383-3404, 2017 04 27.
Article em En | MEDLINE | ID: mdl-28398044
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pancreatite / Inibidores Enzimáticos / Quinurenina 3-Mono-Oxigenase Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pancreatite / Inibidores Enzimáticos / Quinurenina 3-Mono-Oxigenase Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article