Transforming growth factor ß-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.

Ide, Maho; Jinnin, Masatoshi; Tomizawa, Yukiko; Wang, Zhongzhi; Kajihara, Ikko; Fukushima, Satoshi; Hashizume, Yoshinobu; Asano, Yoshihide; Ihn, Hironobu

Ide, Maho; Jinnin, Masatoshi; Tomizawa, Yukiko; Wang, Zhongzhi; Kajihara, Ikko; Fukushima, Satoshi; Hashizume, Yoshinobu; Asano, Yoshihide; Ihn, Hironobu.

Afiliação

Ide M; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Jinnin M; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Tomizawa Y; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Wang Z; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kajihara I; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Fukushima S; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hashizume Y; RIKEN Program for Drug Discovery and Medical Technology Platforms, Wako, Saitama, Japan.
Asano Y; Department of Dermatology, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Ihn H; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Exp Dermatol ; 26(11): 1139-1143, 2017 11.

Article em En | MEDLINE | ID: mdl-28418584

Assuntos

Colágeno Tipo I/metabolismo; Fibrose/prevenção & controle; Pirazóis/farmacologia; Piridinas/farmacologia; Escleroderma Sistêmico/metabolismo; Pele/patologia; Fator de Crescimento Transformador beta/antagonistas & inibidores; Actinas/metabolismo; Aminoácidos/farmacologia; Aminopiridinas/farmacologia; Animais; Bleomicina; Cadeia alfa 1 do Colágeno Tipo I; Fator de Crescimento do Tecido Conjuntivo/metabolismo; Fibroblastos; Fibrose/induzido quimicamente; Humanos; Concentração Inibidora 50; Camundongos; Fenóis/farmacologia; Pirazóis/uso terapêutico; Piridinas/uso terapêutico; Pirróis/farmacologia; Escleroderma Sistêmico/patologia; Transdução de Sinais/efeitos dos fármacos; Fator de Crescimento Transformador beta/metabolismo; Fator de Crescimento Transformador beta/farmacologia; Regulação para Cima/efeitos dos fármacos; Xantenos/farmacologia

Palavras-chave

fibrosis; scleroderma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Escleroderma Sistêmico / Pele / Fibrose / Fator de Crescimento Transformador beta / Colágeno Tipo I Tipo de estudo: Clinical_trials Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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