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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells.
Pan, Feng; Wingo, Thomas S; Zhao, Zhigang; Gao, Rui; Makishima, Hideki; Qu, Guangbo; Lin, Li; Yu, Miao; Ortega, Janice R; Wang, Jiapeng; Nazha, Aziz; Chen, Li; Yao, Bing; Liu, Can; Chen, Shi; Weeks, Ophelia; Ni, Hongyu; Phillips, Brittany Lynn; Huang, Suming; Wang, Jianlong; He, Chuan; Li, Guo-Min; Radivoyevitch, Tomas; Aifantis, Iannis; Maciejewski, Jaroslaw P; Yang, Feng-Chun; Jin, Peng; Xu, Mingjiang.
Afiliação
  • Pan F; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
  • Wingo TS; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
  • Zhao Z; Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA.
  • Gao R; Departments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
  • Makishima H; Neurology, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
  • Qu G; Division of Neurology, Department of Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA.
  • Lin L; Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
  • Yu M; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
  • Ortega JR; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Wang J; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
  • Nazha A; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
  • Chen L; Departments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
  • Yao B; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA.
  • Liu C; Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
  • Chen S; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
  • Weeks O; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Ni H; Departments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
  • Phillips BL; Departments of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
  • Huang S; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
  • Wang J; Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1011 NW 15th Street, Room 411, Gautier Building, MC R629, Miami, Florida 33136, USA.
  • He C; Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA.
  • Li GM; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
  • Radivoyevitch T; Department of Biochemistry and Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30307, USA.
  • Aifantis I; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32611, USA.
  • Maciejewski JP; Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Yang FC; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA.
  • Jin P; Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
  • Xu M; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Nat Commun ; 8: 15102, 2017 04 25.
Article em En | MEDLINE | ID: mdl-28440315
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Proteínas Proto-Oncogênicas / Neoplasias Hematológicas / 5-Metilcitosina / Proteínas de Ligação a DNA / Taxa de Mutação Limite: Aged / Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Proteínas Proto-Oncogênicas / Neoplasias Hematológicas / 5-Metilcitosina / Proteínas de Ligação a DNA / Taxa de Mutação Limite: Aged / Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article