Fibrinolysis by rat mesothelial cells in vitro: the effect of mineral dusts at non-toxic doses.
Br J Exp Pathol
; 69(4): 487-94, 1988 Aug.
Article
em En
| MEDLINE
| ID: mdl-2846026
ABSTRACT
Rat mesothelial cell cultures were shown to have considerable plasminogen dependent and independent fibrinolytic activity in vitro using an 125I fibrin degradation assay. At non-toxic doses of the mineral dusts titanium dioxide, quartz and crocidolite asbestos, as assessed by 51Cr release, the fibrinolytic activity of mesothelial cells was inhibited. Quartz had the greatest inhibitory effect and crocidolite asbestos had the least. These results suggests that inhibition of mesothelial cell fibrinolysis does not, on its own, explain pleural fibrosis due to toxic mineral dusts.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pleura
/
Poeira
/
Fibrinólise
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article