GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant <i>Kras</i>-driven pancreatic tumorigenesis in mice.

Shen, Jieli; Ha, Dat P; Zhu, Genyuan; Rangel, Daisy F; Kobielak, Agnieszka; Gill, Parkash S; Groshen, Susan; Dubeau, Louis; Lee, Amy S

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.

Shen, Jieli; Ha, Dat P; Zhu, Genyuan; Rangel, Daisy F; Kobielak, Agnieszka; Gill, Parkash S; Groshen, Susan; Dubeau, Louis; Lee, Amy S.

Afiliação

Shen J; Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Ha DP; Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Zhu G; Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Rangel DF; Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Kobielak A; Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Gill PS; Department of Pathology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Groshen S; Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Dubeau L; Department of Pathology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176.
Lee AS; Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176; amylee@usc.edu.

Proc Natl Acad Sci U S A ; 114(20): E4020-E4029, 2017 05 16.

Article em En | MEDLINE | ID: mdl-28461470

Assuntos

Carcinoma Ductal Pancreático/genética; Transdiferenciação Celular; Proteínas de Choque Térmico/genética; Pâncreas/patologia; Neoplasias Pancreáticas/genética; Células Acinares/metabolismo; Animais; Carcinogênese; Carcinoma Ductal Pancreático/metabolismo; Carcinoma Ductal Pancreático/patologia; Chaperona BiP do Retículo Endoplasmático; Feminino; Haploinsuficiência; Proteínas de Choque Térmico/metabolismo; Masculino; Metaplasia; Camundongos; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patologia; Fator de Crescimento Transformador alfa/metabolismo

Palavras-chave

GRP78; Kras; acinar-to-ductal metaplasia; glucose-regulated protein 78; pancreatic ductal adenocarcinoma

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pâncreas / Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Transdiferenciação Celular / Proteínas de Choque Térmico Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google