Tomographic studies of rCBF with [99mTc]-HM-PAO SPECT in patients with brain tumors: comparison with C15O2 continuous inhalation technique and PET.
J Cereb Blood Flow Metab
; 8(6): S90-4, 1988 Dec.
Article
em En
| MEDLINE
| ID: mdl-2848045
ABSTRACT
In 10 patients with malignant gliomas, the intracerebral distribution of [99mTc]-hexamethylpropylene-amine oxime [( 99mTc]-HM-PAO) was studied with single photon emission computed tomography (SPECT) in comparison with C15O2 steady-state inhalation technique to measure cerebral blood flow using positron emission tomography (PET). In all instances, the cerebral [99mTc]-HM-PAO distribution was comparable with the regional pattern of cerebral blood flow (rCBF) observed with PET. This was confirmed by a significant correlation of tumor to cortex and tumor to white matter ratios between these two experimental methods. However, the contrast between high and low activity regions in the SPECT scans was significantly less than that in the PET scans. Contrast enhancement of the SPECT scans was accomplished using a correction formula proposed by Lassen.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Oximas
/
Radioisótopos de Oxigênio
/
Neoplasias Encefálicas
/
Tomografia Computadorizada de Emissão
/
Circulação Cerebrovascular
/
Tecnécio
/
Glioblastoma
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article