Inhibition of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferases by MAM-2201 in human liver microsomes.

Kong, Tae Yeon; Kim, Ju-Hyun; Kwon, Soon-Sang; Cheong, Jae Chul; Kim, Hee Seung; In, Moon Kyo; Lee, Hye Suk

Kong, Tae Yeon; Kim, Ju-Hyun; Kwon, Soon-Sang; Cheong, Jae Chul; Kim, Hee Seung; In, Moon Kyo; Lee, Hye Suk.

Afiliação

Kong TY; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14662, Republic of Korea.
Kim JH; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14662, Republic of Korea.
Kwon SS; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14662, Republic of Korea.
Cheong JC; Forensic Chemistry Laboratory, Forensic Science Division, Supreme Prosecutor's Office, 157 Banpo-daero, Seocho-gu, Seoul, 06590, Republic of Korea.
Kim HS; Forensic Chemistry Laboratory, Forensic Science Division, Supreme Prosecutor's Office, 157 Banpo-daero, Seocho-gu, Seoul, 06590, Republic of Korea.
In MK; Forensic Chemistry Laboratory, Forensic Science Division, Supreme Prosecutor's Office, 157 Banpo-daero, Seocho-gu, Seoul, 06590, Republic of Korea.
Lee HS; Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 14662, Republic of Korea. sianalee@catholic.ac.kr.

Arch Pharm Res ; 40(6): 727-735, 2017 Jun.

Article em En | MEDLINE | ID: mdl-28484907

Assuntos

Sistema Enzimático do Citocromo P-450/metabolismo; Inibidores Enzimáticos/farmacologia; Glucuronosiltransferase/antagonistas & inibidores; Indóis/farmacologia; Microssomos Hepáticos/efeitos dos fármacos; Naftalenos/farmacologia; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/química; Glucuronosiltransferase/metabolismo; Humanos; Indóis/química; Microssomos Hepáticos/metabolismo; Estrutura Molecular; Naftalenos/química; Relação Estrutura-Atividade

Palavras-chave

Cytochrome P450; Drugdrug interaction; Human liver microsomes; MAM-2201; UDP-glucuronosyltransferase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Glucuronosiltransferase / Sistema Enzimático do Citocromo P-450 / Inibidores Enzimáticos / Indóis / Naftalenos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google