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Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans.
Nakajima, Katsumasa; Chatelain, Ricardo; Clairmont, Kevin B; Commerford, Renee; Coppola, Gary M; Daniels, Thomas; Forster, Cornelia J; Gilmore, Thomas A; Gong, Yongjin; Jain, Monish; Kanter, Aaron; Kwak, Youngshin; Li, Jingzhou; Meyers, Charles D; Neubert, Alan D; Szklennik, Paul; Tedesco, Vivienne; Thompson, James; Truong, David; Yang, Qing; Hubbard, Brian K; Serrano-Wu, Michael H.
Afiliação
  • Nakajima K; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Chatelain R; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Clairmont KB; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Commerford R; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Coppola GM; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Daniels T; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Forster CJ; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Gilmore TA; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Gong Y; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Jain M; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Kanter A; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Kwak Y; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Li J; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Meyers CD; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Neubert AD; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Szklennik P; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Tedesco V; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Thompson J; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Truong D; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Yang Q; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Hubbard BK; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
  • Serrano-Wu MH; Global Discovery Chemistry, ‡Cardiovascular and Metabolism, ∥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 60(11): 4657-4664, 2017 06 08.
Article em En | MEDLINE | ID: mdl-28498655
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Aumento de Peso / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase / Dieta Hiperlipídica / Obesidade Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Aumento de Peso / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase / Dieta Hiperlipídica / Obesidade Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article