Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms.
J Am Chem Soc
; 139(21): 7188-7191, 2017 05 31.
Article
em En
| MEDLINE
| ID: mdl-28502178
ABSTRACT
The oral microbiome is a dynamic environment inhabited by both commensals and pathogens. Among these is Streptococcus mutans, the causative agent of dental caries, the most prevalent childhood disease. Carolacton has remarkably specific activity against S. mutans, causing acid-mediated cell death during biofilm formation; however, its complex structure limits its utility. Herein, we report the diverted total synthesis and biological evaluation of a rationally designed library of simplified analogs that unveiled three unique biofilm phenotypes further validating the role of natural product synthesis in the discovery of new biological phenomena.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptococcus mutans
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Produtos Biológicos
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Biofilmes
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Macrolídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article