Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.

Pearson, S; Williamson, A J K; Blance, R; Somervaille, T C P; Taylor, S; Azadbakht, N; Whetton, A D; Pierce, A

Pearson, S; Williamson, A J K; Blance, R; Somervaille, T C P; Taylor, S; Azadbakht, N; Whetton, A D; Pierce, A.

Afiliação

Pearson S; Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.
Williamson AJK; Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.
Blance R; Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.
Somervaille TCP; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Taylor S; Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.
Azadbakht N; Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.
Whetton AD; Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, University of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK.
Pierce A; Stoller Biomarker Discovery Centre, University of Manchester, Manchester, UK.

Leukemia ; 31(12): 2717-2725, 2017 12.

Article em En | MEDLINE | ID: mdl-28533538

Assuntos

Janus Quinase 2/genética; Mutação; Policitemia Vera/genética; Policitemia Vera/metabolismo; Proteômica; Substituição de Aminoácidos; Linhagem Celular; Códon; Humanos; Janus Quinase 2/metabolismo; Policitemia Vera/tratamento farmacológico; Mapeamento de Interação de Proteínas; Mapas de Interação de Proteínas; Proteoma; Proteômica/métodos; Proteínas Proto-Oncogênicas c-myc/genética; Proteínas Proto-Oncogênicas c-myc/metabolismo; Transdução de Sinais; Fator de Crescimento Transformador beta/metabolismo; Proteína Supressora de Tumor p53/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Policitemia Vera / Proteômica / Janus Quinase 2 / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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