Somatic driver mutations in melanoma.
Cancer
; 123(S11): 2104-2117, 2017 06 01.
Article
em En
| MEDLINE
| ID: mdl-28543693
ABSTRACT
Melanoma has one of the highest somatic mutational burdens among solid malignancies. Although the rapid progress in genomic research has contributed immensely to our understanding of the pathogenesis of melanoma, the clinical significance of the vast array of genomic alterations discovered by next-generation sequencing is far from being fully characterized. Most mutations prevalent in melanoma are simply neutral "passengers," which accompany functionally significant "drivers" under transforming conditions. The delineation of driver mutations from passenger mutations is critical to the development of targeted therapies. Novel advances in genomic data analysis have aided in distinguishing true driver mutations involved in tumor progression. Here, the authors review the current literature on important somatic driver mutations in melanoma, along with the implications for treatment. Cancer 2017;1232104-17. © 2017 American Cancer Society.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Neoplasias Uveais
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Melanoma
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Mutação
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article