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Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Ali, Niwa; Zirak, Bahar; Rodriguez, Robert Sanchez; Pauli, Mariela L; Truong, Hong-An; Lai, Kevin; Ahn, Richard; Corbin, Kaitlin; Lowe, Margaret M; Scharschmidt, Tiffany C; Taravati, Keyon; Tan, Madeleine R; Ricardo-Gonzalez, Roberto R; Nosbaum, Audrey; Bertolini, Marta; Liao, Wilson; Nestle, Frank O; Paus, Ralf; Cotsarelis, George; Abbas, Abul K; Rosenblum, Michael D.
Afiliação
  • Ali N; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
  • Zirak B; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Rodriguez RS; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Pauli ML; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Truong HA; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Lai K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Ahn R; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Corbin K; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Lowe MM; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Scharschmidt TC; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Taravati K; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Tan MR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Ricardo-Gonzalez RR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Nosbaum A; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Bertolini M; Department of Dermatology, University of Muenster, 48149 Muenster, Germany.
  • Liao W; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Nestle FO; Cutaneous Medicine Unit, St. John's Institute of Dermatology, King's College London, London WC2R 2LS, UK.
  • Paus R; Centre for Dermatological Research, University of Manchester & NIHR Manchester Biomedical Research Centre, Manchester M13 9PL, UK.
  • Cotsarelis G; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Abbas AK; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Rosenblum MD; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: michael.rosenblum@ucsf.edu.
Cell ; 169(6): 1119-1129.e11, 2017 Jun 01.
Article em En | MEDLINE | ID: mdl-28552347
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregs and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Linfócitos T Reguladores / Folículo Piloso Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Linfócitos T Reguladores / Folículo Piloso Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article