Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

Göckeritz, Elisa; Vondey, Verena; Guastafierro, Anna; Pizevska, Maja; Hassenrück, Floyd; Neumann, Lars; Hallek, Michael; Krause, Günter

Göckeritz, Elisa; Vondey, Verena; Guastafierro, Anna; Pizevska, Maja; Hassenrück, Floyd; Neumann, Lars; Hallek, Michael; Krause, Günter.

Afiliação

Göckeritz E; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Vondey V; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Guastafierro A; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Pizevska M; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Hassenrück F; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Neumann L; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Hallek M; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.
Krause G; Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.

Br J Haematol ; 178(6): 949-953, 2017 09.

Article em En | MEDLINE | ID: mdl-28573668

Assuntos

Linfócitos B/enzimologia; Leucemia de Células B/genética; Linfoma de Células B/genética; Proteínas Tirosina Quinases/genética; Adenina/análogos & derivados; Tirosina Quinase da Agamaglobulinemia; Antineoplásicos; Quimiocinas/metabolismo; Quimiotaxia/efeitos dos fármacos; Dasatinibe/administração & dosagem; Dasatinibe/farmacologia; Relação Dose-Resposta a Droga; Resistencia a Medicamentos Antineoplásicos/genética; Humanos; Leucemia de Células B/enzimologia; Leucemia de Células B/patologia; Linfoma de Células B/enzimologia; Linfoma de Células B/patologia; Mutação; Fosforilação/efeitos dos fármacos; Piperidinas; Inibidores de Proteínas Quinases/farmacologia; Proteínas Tirosina Quinases/antagonistas & inibidores; Proteínas Tirosina Quinases/metabolismo; Pirazóis/administração & dosagem; Pirazóis/farmacologia; Pirimidinas/administração & dosagem; Pirimidinas/farmacologia; Células Tumorais Cultivadas

Palavras-chave

B cell malignancies; chemokine secretion; chemotaxis; resistance mutations; tyrosine kinase inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Linfócitos B / Leucemia de Células B / Linfoma de Células B Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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