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Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Scott, Daniel C; Hammill, Jared T; Min, Jaeki; Rhee, David Y; Connelly, Michele; Sviderskiy, Vladislav O; Bhasin, Deepak; Chen, Yizhe; Ong, Su-Sien; Chai, Sergio C; Goktug, Asli N; Huang, Guochang; Monda, Julie K; Low, Jonathan; Kim, Ho Shin; Paulo, Joao A; Cannon, Joe R; Shelat, Anang A; Chen, Taosheng; Kelsall, Ian R; Alpi, Arno F; Pagala, Vishwajeeth; Wang, Xusheng; Peng, Junmin; Singh, Bhuvanesh; Harper, J Wade; Schulman, Brenda A; Guy, R Kip.
Afiliação
  • Scott DC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Hammill JT; Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Min J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Rhee DY; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Connelly M; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
  • Sviderskiy VO; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Bhasin D; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Chen Y; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Ong SS; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Chai SC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Goktug AN; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Huang G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Monda JK; Laboratory of Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Low J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Kim HS; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Paulo JA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Cannon JR; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
  • Shelat AA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
  • Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Kelsall IR; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Alpi AF; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK.
  • Pagala V; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.
  • Wang X; St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Peng J; St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Singh B; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Harper JW; St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Schulman BA; Laboratory of Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Guy RK; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Nat Chem Biol ; 13(8): 850-857, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28581483
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitinas / Ubiquitina-Proteína Ligases / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitinas / Ubiquitina-Proteína Ligases / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article