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Prevalence of pregnancy-relevant infections in a rural setting of Ghana.
Völker, Fabian; Cooper, Paul; Bader, Oliver; Uy, Angela; Zimmermann, Ortrud; Lugert, Raimond; Groß, Uwe.
Afiliação
  • Völker F; Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, D-37075, Göttingen, Germany.
  • Cooper P; St. Martin de Porres Hospital, Eikwe, W/R, Ghana.
  • Bader O; Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, D-37075, Göttingen, Germany.
  • Uy A; Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, D-37075, Göttingen, Germany.
  • Zimmermann O; Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, D-37075, Göttingen, Germany.
  • Lugert R; Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, D-37075, Göttingen, Germany.
  • Groß U; Institute for Medical Microbiology, University Medical Center Göttingen, Kreuzbergring 57, D-37075, Göttingen, Germany. ugross@gwdg.de.
BMC Pregnancy Childbirth ; 17(1): 172, 2017 Jun 06.
Article em En | MEDLINE | ID: mdl-28583150
ABSTRACT

BACKGROUND:

Although infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal and child health are missing.

METHODS:

We conducted a cross-sectional, single-centre pilot study in a rural area of Ghana to assess the infectiological profile during pregnancy. Screening of 180 expectant mothers was done by vaginal swabs and serology to detect the most common pregnancy-relevant infections. They were also interviewed for potential risk factors, outcome of previous pregnancies, and socio-economic aspects.

RESULTS:

We found a high prevalence of infections caused by hepatitis B virus (16.7% HBs antigen positive). In contrast, infections caused by hepatitis C virus (1.1% anti-HCV) and HIV (0.6%) were rare. Maternal malaria was frequent (10.6%), despite increasing acceptance of intermittent preventive treatment during pregnancy (IPTp). Group B streptococci were present in 10.6% of all pregnant women. Absence of antibodies against varicella zoster virus in 43.2%, Toxoplasma gondii in 26.8%, parvovirus B19 in 20.0%, and rubella virus in 15.7% makes a significant proportion of pregnant women susceptible for acquiring primary infections. Whereas all study participants had specific IgG antibodies against human cytomegalovirus, infections with Listeria, Brucella, or Neisseria gonorrhoeae as well as active syphilis were absent.

CONCLUSIONS:

Our pilot study in a rural community in Ghana indicates an urgent need for action in dealing at least with high-prevalent pregnancy-relevant infections, such as hepatitis B, malaria and those caused by group B streptococci. In addition, the resulting prevalence rates of various other infections may offer guidance for health officials to prioritize possible future intervention schemes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / População Rural / Hepatite C / Hepatite B / Malária Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy País/Região como assunto: Africa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / População Rural / Hepatite C / Hepatite B / Malária Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy País/Região como assunto: Africa Idioma: En Ano de publicação: 2017 Tipo de documento: Article