The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway.

Luo, Jiaming; Chen, Rong; Zeng, Siyu; Yu, Juming; Jiang, Guohui; Wang, Li; Qin, Xinyue

Luo, Jiaming; Chen, Rong; Zeng, Siyu; Yu, Juming; Jiang, Guohui; Wang, Li; Qin, Xinyue.

Afiliação

Luo J; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Chen R; Department of Microbiology and Immunology, North Sichuan Medical College, Nanchong 637000, China.
Zeng S; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Yu J; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Jiang G; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Wang L; Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Qin X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: qinxinyue@yahoo.com.

Biochem Biophys Res Commun ; 490(3): 927-932, 2017 08 26.

Article em En | MEDLINE | ID: mdl-28655617

Assuntos

Berberina/uso terapêutico; Encefalomielite Autoimune Experimental/tratamento farmacológico; Lisofosfolipídeos/metabolismo; Esclerose Múltipla/tratamento farmacológico; Fármacos Neuroprotetores/uso terapêutico; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Esfingosina/análogos & derivados; Animais; Berberina/farmacologia; Encefalomielite Autoimune Experimental/metabolismo; Encefalomielite Autoimune Experimental/patologia; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Esclerose Múltipla/metabolismo; Esclerose Múltipla/patologia; Fármacos Neuroprotetores/farmacologia; Transdução de Sinais/efeitos dos fármacos; Esfingosina/metabolismo; Medula Espinal/metabolismo; Medula Espinal/patologia

Palavras-chave

Astrocytes; BBR; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Sphingosine kinase-1; Sphingosine-1-phosphate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingosina / Berberina / Lisofosfolipídeos / Fosfotransferases (Aceptor do Grupo Álcool) / Fármacos Neuroprotetores / Encefalomielite Autoimune Experimental / Esclerose Múltipla Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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