V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients.
J Biomed Sci
; 24(1): 43, 2017 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-28697735
ABSTRACT
BACKGROUND:
Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythropoietin (EPO) has been used as an effective treatment for ESRD patients with anemia, a large number of patients still present poor responses to EPO treatment.METHODS:
We measured T-cell receptor sequencing profiles, including length of complementarity-deteremining region 3 (CDR3), intra- and inter-group (EPO resistant vs. responsive) clonotype diversity, V(D)J usage profiles and V-J combinations from ESRD patients and to investigate the correlation between these features and EPO treatment efficacy.RESULTS:
Our results revealed statistical significance in the top 3 ~ 15 most abundant joint distributions of Vß/Jß among the two groups, suggesting the importance of V or J gene utilization in the EPO response of ESRD patients.CONCLUSIONS:
In summary, we provided evidence addressing the potential correlation between the immune repertoire and EPO response in ESRD patients. TRIAL REGISTRATION TMU-JIRB 201309026. Registered 16 October 2013.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Eritropoetina
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Anemia
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Falência Renal Crônica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article