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Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.
Zhang, Ping; Lee, Jason S; Gartlan, Kate H; Schuster, Iona S; Comerford, Iain; Varelias, Antiopi; Ullah, Md Ashik; Vuckovic, Slavica; Koyama, Motoko; Kuns, Rachel D; Locke, Kelly R; Beckett, Kirrilee J; Olver, Stuart D; Samson, Luke D; Montes de Oca, Marcela; de Labastida Rivera, Fabian; Clouston, Andrew D; Belz, Gabrielle T; Blazar, Bruce R; MacDonald, Kelli P; McColl, Shaun R; Thomas, Ranjeny; Engwerda, Christian R; Degli-Esposti, Mariapia A; Kallies, Axel; Tey, Siok-Keen; Hill, Geoffrey R.
Afiliação
  • Zhang P; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. ping.zhang@qimrberghofer.edu.au geoff.hill@qimrberghofer.edu.au.
  • Lee JS; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Gartlan KH; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Schuster IS; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley, Western Australia, Australia.
  • Comerford I; Centre for Experimental Immunology, Lions Eye Institute, Perth, Western Australia, Australia.
  • Varelias A; Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.
  • Ullah MA; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Vuckovic S; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Koyama M; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Kuns RD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Locke KR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Beckett KJ; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Olver SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Samson LD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Montes de Oca M; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • de Labastida Rivera F; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Clouston AD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Belz GT; Envoi Pathology, Brisbane, Queensland 4006, Australia.
  • Blazar BR; Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia.
  • MacDonald KP; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia.
  • McColl SR; Pediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN 55454, USA.
  • Thomas R; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Engwerda CR; Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.
  • Degli-Esposti MA; University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.
  • Kallies A; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Tey SK; Immunology and Virology Program, Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley, Western Australia, Australia.
  • Hill GR; Centre for Experimental Immunology, Lions Eye Institute, Perth, Western Australia, Australia.
Sci Immunol ; 2(10)2017 Apr 07.
Article em En | MEDLINE | ID: mdl-28738016
ABSTRACT
Type 1 regulatory T (TR1) cells are Foxp3- interleukin-10 (IL-10)-producing CD4+ T cells with potent immunosuppressive properties, but their requirements for lineage development have remained elusive. We show that TR1 cells constitute the most abundant regulatory population after allogeneic bone marrow transplantation (BMT), express the transcription factor Eomesodermin (Eomes), and are critical for the prevention of graft-versus-host disease. We demonstrate that Eomes is required for TR1 cell differentiation, during which it acts in concert with the transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) by transcriptionally activating IL-10 expression and repressing differentiation into other T helper cell lineages. We further show that Eomes induction in TR1 cells requires T-bet and donor macrophage-derived IL-27. Thus, we define the cellular and transcriptional control of TR1 cell differentiation during BMT, opening new avenues to therapeutic manipulation.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article