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Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.
Ryan, Gemma M; McLeod, Victoria M; Mehta, Dharmini; Kelly, Brian D; Stanislawski, Pauline C; Owen, David J; Kaminskas, Lisa M; Porter, Christopher J H.
Afiliação
  • Ryan GM; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
  • McLeod VM; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
  • Mehta D; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
  • Kelly BD; Starpharma Pty Ltd, Melbourne, VIC, Australia.
  • Stanislawski PC; Starpharma Pty Ltd, Melbourne, VIC, Australia.
  • Owen DJ; Starpharma Pty Ltd, Melbourne, VIC, Australia.
  • Kaminskas LM; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
  • Porter CJH; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. Elect
Nanomedicine ; 13(8): 2485-2494, 2017 Nov.
Article em En | MEDLINE | ID: mdl-28821463
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Portadores de Fármacos / Metotrexato / Dendrímeros / Linfonodos / Antimetabólitos Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Portadores de Fármacos / Metotrexato / Dendrímeros / Linfonodos / Antimetabólitos Antineoplásicos Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article