Continuous Glucose Monitoring Versus Usual Care in Patients With Type 2 Diabetes Receiving Multiple Daily Insulin Injections: A Randomized Trial.
Ann Intern Med
; 167(6): 365-374, 2017 09 19.
Article
em En
| MEDLINE
| ID: mdl-28828487
ABSTRACT
Background:
Continuous glucose monitoring (CGM), which studies have shown is beneficial for adults with type 1 diabetes, has not been well-evaluated in those with type 2 diabetes receiving insulin.Objective:
To determine the effectiveness of CGM in adults with type 2 diabetes receiving multiple daily injections of insulin.Design:
Randomized clinical trial. (The protocol also included a type 1 diabetes cohort in a parallel trial and subsequent second trial.) (ClinicalTrials.gov NCT02282397).Setting:
25 endocrinology practices in North America. Patients 158 adults who had had type 2 diabetes for a median of 17 years (interquartile range, 11 to 23 years). Participants were aged 35 to 79 years (mean, 60 years [SD, 10]), were receiving multiple daily injections of insulin, and had hemoglobin A1c (HbA1c) levels of 7.5% to 9.9% (mean, 8.5%). Intervention Random assignment to CGM (n = 79) or usual care (control group, n = 79). Measurements The primary outcome was HbA1c reduction at 24 weeks.Results:
Mean HbA1c levels decreased to 7.7% in the CGM group and 8.0% in the control group at 24 weeks (adjusted difference in mean change, -0.3% [95% CI, -0.5% to 0.0%]; P = 0.022). The groups did not differ meaningfully in CGM-measured hypoglycemia or quality-of-life outcomes. The CGM group averaged 6.7 days (SD, 0.9) of CGM use per week.Limitation:
6-month follow-up.Conclusion:
A high percentage of adults who received multiple daily insulin injections for type 2 diabetes used CGM on a daily or near-daily basis for 24 weeks and had improved glycemic control. Because few insulin-treated patients with type 2 diabetes currently use CGM, these results support an additional management method that may benefit these patients. Primary Funding Source Dexcom.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Automonitorização da Glicemia
/
Diabetes Mellitus Tipo 2
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Hipoglicemiantes
/
Insulina
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article