Anti-inflammatory and antioxidant potential of Guaianolide isolated from Cyathocline purpurea: Role of COX-2 inhibition.

Tambewagh, Urmila U; Kandhare, Amit D; Honmore, Varsha S; Kadam, Parag P; Khedkar, Vijay M; Bodhankar, Subhash L; Rojatkar, Supada R

Tambewagh, Urmila U; Kandhare, Amit D; Honmore, Varsha S; Kadam, Parag P; Khedkar, Vijay M; Bodhankar, Subhash L; Rojatkar, Supada R.

Afiliação

Tambewagh UU; R&D Centre in Pharmaceutical Sciences and Applied Chemistry, Bharati Vidyapeeth Deemed University, Pune, Maharashtra 411 038, India.
Kandhare AD; Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra 411 038, India.
Honmore VS; Post Graduate and Research Centre, Department of Chemistry, MES Abasaheb Garware College, Pune, Maharashtra 411 004, India.
Kadam PP; Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra 411 038, India.
Khedkar VM; Department of Pharmaceutical Chemistry, SVKM's Institute of Pharmacy, Survey No. 499, Plot No-03, Mumbai, Agra National Highway, Maharashtra 424001, India.
Bodhankar SL; Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra 411 038, India. Electronic address: drslbodh@gmail.com.
Rojatkar SR; R&D Centre in Pharmaceutical Sciences and Applied Chemistry, Bharati Vidyapeeth Deemed University, Pune, Maharashtra 411 038, India. Electronic address: srojatkar@yahoo.com.

Int Immunopharmacol ; 52: 110-118, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28888779

Assuntos

Anti-Inflamatórios/uso terapêutico; Antioxidantes/uso terapêutico; Ciclo-Oxigenase 2/metabolismo; Edema/tratamento farmacológico; Inflamação/tratamento farmacológico; Fitoterapia/métodos; Sesquiterpenos de Guaiano/uso terapêutico; Animais; Asteraceae/imunologia; Compostos de Bifenilo/imunologia; Carragenina/toxicidade; Células Cultivadas; Edema/induzido quimicamente; Feminino; Humanos; Peróxido de Hidrogênio/metabolismo; Masculino; Camundongos; Estresse Oxidativo/efeitos dos fármacos; Picratos/imunologia; Ratos; Ratos Wistar

Palavras-chave

6α-hydroxy-4 [14], 10 [15]-guainadien-8α, 12-olide; Anti-inflammatory; Antioxidant; COX-2 inhibitors; Cyathocline purpurea; Molecular docking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos de Guaiano / Edema / Ciclo-Oxigenase 2 / Inflamação / Fitoterapia / Anti-Inflamatórios / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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